1. Statins
These drugs reduce LDL blood levels and reduce the build-up of artery
blocking plaques by up to 40%, thereby limiting the possibility of
the release of plaques as dangerous blood clots. Some also raise HDL
cholesterol and lower triglycerides. Statins are the most widely prescribed
drugs for lowering cholesterol.
The most common ones include:
* Lovastatin (Mevacor)
* Simvastatin (Zocor)
* Atorvastatin (Lipitor), a new, highly potent drug
Common side effects of statins include:
* Gastrointestinal upsets
* Liver damage
* Muscle aches
2. Nicotinic Acid (or niacin)
Large doses of the vitamin niacin have been shown to lower triglycerides.
Furthermore, niacin (or nicotinic acid) can lower LDL (bad) cholesterol
and increase HDL (good) cholesterol.
3. Fibric Acids
These increase the liver’s oxidation of fatty acids, thus
resulting in the lowering of LDL cholesterol and triglycerides.
Among these drugs are:
* Clofibrate (Atromed -S)
* Fenofibrate (Tricor)
* Gemfibrozil (Lopid)
The most common side effect is an upset stomach.
4. Bile-Acid Resins
These drugs function by binding with bile acids, and consequently
disrupting the liver’s cholesterol making activities. Bile-acid
resins are usually a second choice to the statins.
These include:
* Colestipol (Colestid)
* Cholestyramine (Questran, LoCholest, and Prevalito).
Common side effects include constipation, gas and constant feeling
of fullness in the stomach.
These conventional treatments are given when cholesterol has risen
to unacceptable levels, and lifestyle changes will not have any
impact in terms of lowering cholesterol levels. These drugs can
be fairly expensive and are often required for many years. It is
also important to note that some of these drugs have dangerous side
effects. For example, the statins have a one-dimensional effect
of reducing the body's ability to synthesize cholesterol. They do
not, however, distinguish between the 'bad' cholesterol (LDL) and
the 'good' cholesterol (HDL) and can also reduce levels of Co-enzyme
Q10 and L-carnitine, two very important molecules which are involved
in energy production and fat metabolism.
Myalgia and even stomach, lung and liver tumors have also been
associated with the use of these drugs. Regular monitoring is quintessential
for people under such medication.
The cliché, prevention is better than the cure,
holds significant importance as lifestyle management in conjunction
with beneficial supplements can keep cholesterol in check over a
long period of time.
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