Over time, plaque causes the arteries to become narrower, decreasing
blood flow and causing a condition called atherosclerosis.

When atherosclerosis affects the coronary arteries (the blood vessels
that supply the muscles of the heart), the condition is called coronary
artery disease (CAD).

Large plaque areas can lead to chest pain called angina. This condition
is triggered by the lack of blood and oxygen to the heart. Angina
is a common sign of CAD.

Rupture of cholesterol plaques can lead to the formation of blood
clots. These block the flow of blood to parts of the heart muscle
and cause a heart attack.

When atherosclerosis affects the blood vessels that supply the brain,
the condition is called cerebral vascular disease, which puts a
person at risk of having a stroke.
The levels of HDL, LDL and total cholesterol are all indicators
for atherosclerosis and heart attack risk. People who have a cholesterol
level of 275 or greater are at significant risk for a heart attack,
despite a favorable HDL level. In addition, people who have normal
cholesterol levels but low HDL levels are also at increased risk
for a heart attack. The main goal in lowering cholesterol is to
lower LDL level and raise the HDL level. Ideally, cholesterol levels
should be tested every three to five years. The medical community
uses the following guidelines to ascertain the risk of heart disease: